Originally aired April 30, 2014: Cardiovascular risk and testosterone supplementation, reducing time to treatment in acute ischemic stroke.

Fahad and Amol want you to:

1. Recognize that observational evidence suggests that testosterone supplementation is significantly associated with cardiovascular events and mortality.

2. Understand that a national quality improvement initiative was associated with reduced treatment times for stroke and improved clinical outcomes.

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The papers

Rebecca Vigen et al. Association of Testosterone Therapy With Mortality, Myocardial Infarction, and Stroke in Men With Low Testosterone Levels. JAMA. 2013;310(17):1829-183.

Gregg C Fonarow et al. Door-to-Needle Times for Tissue Plasminogen Activator Administration and Clinical Outcomes in Acute Ischemic Stroke Before and After a Quality Improvement Initiative. JAMA. 2014;311(16):1632-1640.

Good stuff

Fahad – How Doctors Die: Showing Others the Way, Dan Gorenstein, New York Times, November 19, 2013. 

Amol – Jonas Salk: Good at Virology, Bad at Economics, Brian Palmer, Slate.com, April 13, 2014.