Obstetrical Medicine Special: Hypertension and Thrombophilia in Pregnancy


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The CHIPS trial of Hypertension in Pregnancy and TIPPS trial of Thrombophilia in Pregnancy

Janice and Amol want you to understand the following:

1. Tight blood pressure control in pregnancy does not affect fetal outcomes in pregnancy compared with loose blood pressure control. The only difference in maternal outcomes is a reduced risk of severe hypertension in the tight blood pressure control group.

2. Low molecular weight heparin does not improve pregnancy outcomes in women with thrombophilia.

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The papers

LA Magee et al. Less-Tight versus Tight Control of Hypertension in Pregnancy. N Engl J Med. 2015 Jan 29;372(5):407-17. (PubMed).

MA Rodger et al. Antepartum dalteparin versus no antepartum dalteparin for the prevention of pregnancy complications in pregnant women with thrombophilia (TIPPS): a multinational open-label randomised trial. Lancet. 2014 Nov 8;384(9955):1673-83. (PubMed).

Good stuff

My Own Life: Oliver Sacks on Learning He Has Terminal Cancer. New York Times. 2015 Feb 19. 

John Evans, founder of MaRS, dead at 85. Marco Chown Oved. Toronto Star. 2015 Feb 13.

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