Heart Success! Bilateral mastectomies in breast cancer, the PARADIGM-HF Heart Failure Trial


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This week: Changes in incidence and mortality associated with bilateral mastectomy for breast cancer and Neprilysin-inhibition for heart failure

Nathan and Amol want you to:

1. Recognize that bilateral mastectomies for breast cancer are increasing in incidence, perhaps because of increased use of MRI, and they are not associated with a reduction in mortality.

2. Understand that the PARADIGM-HF trial demonstrated that neprilysin-inhibition in heart failure reduced mortality compared to ace-inhibition, which may change treatment of this important disease.

Continuing Medical Education

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The papers

AW Kurian et al. Use of and Mortality After Bilateral Mastectomy Compared With Other Surgical Treatments for Breast Cancer in California, 1998-2011. JAMA 2014;312(9):902-914. (PubMed).

JJ McMurray et al. Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure. N Engl J Med 2014; 371:993-1004. (PubMed). 

Good stuff

Nathan:

Why it makes sense to bike without a helmet, Howie Chong, February 24, 2014.

Amol:

President’s Valedictory Address: Dr. Louis Hugo Francescutti, Canadian Medical Association (Video).

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