Heart Success! Bilateral mastectomies in breast cancer, the PARADIGM-HF Heart Failure Trial
This week: Changes in incidence and mortality associated with bilateral mastectomy for breast cancer and Neprilysin-inhibition for heart failure
Nathan and Amol want you to:
1. Recognize that bilateral mastectomies for breast cancer are increasing in incidence, perhaps because of increased use of MRI, and they are not associated with a reduction in mortality.
2. Understand that the PARADIGM-HF trial demonstrated that neprilysin-inhibition in heart failure reduced mortality compared to ace-inhibition, which may change treatment of this important disease.
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