How I Met Your D-dimer: Weight loss, pulmonary embolism, and HIV
This week: Weight loss in colorectal cancer screening, D-dimers in Pulmonary Embolism, and Gene Editing in HIV
Nathan, Amol and Travis want you to:
1. Recognize that modifiable lifestyle factors such as inactivity, weight, diet, and alcohol consumption are under-appreciated risk factors for colorectal cancer.
2. Understand how a weight loss and lifestyle improvement intervention timed with colorectal screening was found to lead to more clinically significant weight loss and lifestyle changes compared to usual care.
3. Understand the potential implications of age-adjusted cutoffs for D-dimer levels in pulmonary embolism.
4. Understand the novel therapeutic strategy of gene editing of T-cells for HIV.
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Annie S Anderson et al. The impact of a bodyweight and physical activity intervention (BeWEL) initiated through a national colorectal cancer screening programme: randomised controlled trial. BMJ. 2014;348:g1823. (PubMed).