SARAH’s VOICE: Pre-exposure prophylaxis in HIV and exercise for the rheumatoid hand


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VOICE: Tenofovir and Emtricitabine for HIV pre-exposure prophylaxis in African women and SARAH: Hand exercises in Rheumatoid Arthritis

Fahad and Amol want you to understand the following:

1. Pre-exposure prophylaxis was not effective in a population of African women. Medication adherence was apparently excellent based on self-report and pill counting, however serum drug levels demonstrated that it was actually very poor.
2. A structured hand exercise regimen was effective in improving function, self-confidence, and quality of life in patients with Rheumatoid Arthritis.

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The papers

Marrazzo JM, Ramjee G, Richardson BA, et al. Tenofovir-Based Preexposure Prophylaxis for HIV Infection among African Women. N Engl J Med. 2015 Feb 5;372(6):509-18. (PubMed).

Saag MS. Preventing HIV in women-still trying to find their VOICE. N Engl J Med. 2015 Feb 5;372(6):564-6. (PubMed).

A Failed Trial in Africa Raises Questions About How to Test H.I.V. Drugs. Donald McNeil Jr. New York Times. 2015 Feb 4.

Good stuff

Pregnant, and Disputing the Doctor. Catherine Saint Louis. New York Times: Well Blog. 2013 Aug 9.

John Ioannidis Interview. Julia Belluz. Vox.com. 2015 Feb 16.

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