PURE at HEART: Fats vs. Carbohydrates as Risk Factors for Mortality and Stratifying Chest Pain in the Emergency Department


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What’s healthier, a diet high in fat or high in carbohydrates? How can the HEART score be used to stratify patients who present to the Emergency Department with chest pain? Kieran Quinn and Ashley Minuk cover the answers from the findings of two exciting new articles.

With the growing burden of cardiovascular and diet related disease there is a widespread effort to update dietary guidelines. Ashley covers a prospective multi-national cohort study which adds evidence to the impact of various macronutrients – carbohydrates, proteins, fats – on mortality and cardiovascular events.

Next, Kieran guides listeners through the results of a trial of the HEART score, an easy-to-apply instrument to stratify patients with chest pain according to their short term risk for major adverse cardiac events.

Finally, the Good Stuff segment. Gene therapy is here! Kieran covers a new FDA approved treatment for leukemia. Ashley covers the exercise paradox: physical activity may do less than one would hope to control weight.

Like what you hear? Rate us on iTunes! Chat with us on Twitter @roundstable and tweet at Kieran @kieranlquinn and Ashley @ashleyminuk

The Papers

1. PURE: http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32252-3/abstract

2. HEART Score: http://annals.org/aim/article/2622872/effect-using-heart-score-patients-chest-pain-emergency-department-stepped

Good Stuff

1. To fight from within: https://mobile.nytimes.com/2017/08/30/health/gene-therapy-cancer.html?referer

2. In you Jeans? https://www.scientificamerican.com/article/the-exercise-paradox/

Music Credits

The Rounds Table Theme Music by Brendan Quinn, Creative Director and Composer, Vapor RMW

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