What the Heart Wants: Takotsubo Cardiomyopathy and Cardiovascular Benefits of Empagliflozen


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The “broken heart syndrome” – not always caused by a broken heart? A multi-national, multi-centered observational study on takotsubo cardiomyopathy found that physical triggers are more common than emotional triggers, patients present predominantly with chest pain, ECG changes, and troponin elevation. The study also generated surprising hypotheses about what medications have long-term benefit for these patients.

This is the first time a glucose lowering drug has been shown to decrease cardiovascular mortality in Type 2 diabetes! A randomized control trial found empagliflozen had significant cardiovascular benefits in Type 2 diabetics with established cardiovascular disease. For every 38 patients treated with empagliflozen for three years, one would be saved from death. Is this impressive result due to better glycemic control, or another effect of the drug?

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The papers

1. Takotsubo cardiomyopathy: http://www.nejm.org/doi/full/10.1056/NEJMoa1406761

2. Cardiovascular benefits of empagliflozen: http://www.nejm.org/doi/full/10.1056/NEJMoa1504720

Good Stuff

Music Credits (Creative Commons)

In your Robotic Heart – Nicolai Heidlas https://soundcloud.com/nicolai-heidlas/in-your-robotic-heart

Drive – Nicolai Heidlas https://soundcloud.com/nicolai-heidlas/drive-fresh-upbeat-pop-background-music

Swingin’ Jazz – Nicolai Heidlas ‎https://m.soundcloud.com/nicolai-heidlas/jazz-blues-background-music

“Searching for Jupiter” – Nicolai Heidlas https://soundcloud.com/nicolai-heidlas/searching-for-jupiter

All tracks have been modified for the purposes of this podcast.

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