Article

The known unknowns of COVID-19 vaccines

32 Comments
  • Bernice Herzog says:

    I Had Breast cancer in both breasts ,Lump ectomy in both breast one in 2014 the other in 2020

    and just had knee surgery,Feb 22 2021 I’m wondering should I get the Covid-19 vaccine

  • Iris says:

    “Experts have taken to social media to quell misinformation and address common concerns about Pfizer’s messenger RNA (mRNA) COVID-19 vaccine, performing an important public service in support of robust vaccine uptake. However, some scientific information is being oversimplified to the point that it is misleading. The public’s decision to take a vaccine whose long-term risks are unclear should be a well-informed one. Clear communication is crucial to the process of informed consent and for building public trust in the fight against vaccine hesitancy.”

    https://www.kevinmd.com/blog/2021/01/upholding-the-principles-of-informed-consent-in-the-fight-against-vaccine-hesitancy.html

  • Natalie says:

    Thank you for publishing this educational article. Top COVID-19 Vaccine Questions I read about at https://help-center.pissedconsumer.com/top-covid-19-vaccine-questions-what-health-experts-say/ are usually about the safety of it, side effects, pros and cons. I really worry that we are rushed into vaccination without proper testing and understanding the question.

  • Natalie says:

    Thank you for publishing this educational article. Top COVID-19 Vaccine Questions I read about at https://help-center.pissedconsumer.com/top-covid-19-vaccine-questions-what-health-experts-say/ are usually about the safety of it, side effects, pros and cons. I really worry that we are rushed into vaccination without proper testing and understanding the question.

  • IdPnSD says:

    “News that COVID-19 vaccines are up to 95 per cent effective has scientists cautiously optimistic. But questions remain.” – No data can be trusted, without the knowledge about the process that generated the data. Usually all processes are full of assumptions and all assumptions are false. Here are two interesting examples of false data.

    Before Galileo, two billion people on earth believed the data that proved that the earth is the center of the universe. But Galileo changed everything, and he was jailed for the rest of his life.

    You search one million people and you will not find a single person who will say that he remembers his past life, proving that reincarnation is a false law of nature. But if you search one million babies, from age two to age four, then most likely, you will find at least one baby who will convince you about reincarnation. Take a look at https://www.academia.edu/8353396/Reincarnation_a_Law_of_Nature for some examples. Soul theory is an important concept that medical science ignores.

  • IdPnSD says:

    “News that COVID-19 vaccines are up to 95 per cent effective has scientists cautiously optimistic. But questions remain.” – No data can be trusted, without the knowledge about the process that generated the data. Usually all processes are full of assumptions and all assumptions are false. Here are two interesting examples of false data.

    Before Galileo, two billion people on earth believed the data that proved that the earth is the center of the universe. But Galileo changed everything, and he was jailed for the rest of his life.

    You search one million people and you will not find a single person who will say that he remembers his past life, proving that reincarnation is a false law of nature. But if you search one million babies, from age two to age four, then most likely, you will find at least one baby who will convince you about reincarnation. Take a look at https://www.academia.edu/8353396/Reincarnation_a_Law_of_Nature for some examples. Soul theory is an important concept that medical science ignores.

  • canuc says:

    In history books the year 2020 will become the miracle year
    Year that all sickness were cured, only one left “cov19”

  • canuc says:

    In history books the year 2020 will become the miracle year
    Year that all sickness were cured, only one left “cov19”

  • maude says:

    Thanks. No way are these vaccines going into my body

  • maude says:

    Thanks. No way are these vaccines going into my body

  • Ron says:

    Essential Facts About Covid-19

    “Given the spread of misinformation about Covid-19, Just Facts is providing a trove of rigorously documented facts about this disease and its impacts. These include some essential facts that have been absent or misreported in much of the media’s coverage of this issue.”

    https://wattsupwiththat.com/2020/12/10/essential-facts-about-covid-19/?unapproved=3144245&moderation-hash=b6c98e8425c65eaf3bd897aafe0b60c7#comment-3144245

  • Ron says:

    Essential Facts About Covid-19

    “Given the spread of misinformation about Covid-19, Just Facts is providing a trove of rigorously documented facts about this disease and its impacts. These include some essential facts that have been absent or misreported in much of the media’s coverage of this issue.”

    https://wattsupwiththat.com/2020/12/10/essential-facts-about-covid-19/?unapproved=3144245&moderation-hash=b6c98e8425c65eaf3bd897aafe0b60c7#comment-3144245

  • Jane Wilson says:

    When an antigen only affects a subset of the population, the elderly and the obese and those with underlying conditions or on certain Rx medications, a vaccine is inappropriate. The problem lies with the host, not the virus. But the medical establishment does not want to talk about that, because there is no profit in improving someone’s health. For polio and ebola, a vaccine might be a good idea. For Covid-19 it is absolutely unnecessary and, just like the swine flu vaccine, it is likely to cause more harm than good.
    I recommend the following sites:
    https://2020news.de/en/dr-wodarg-and-dr-yeadon-request-a-stop-of-all-corona-vaccination-studies-and-call-for-co-signing-the-petition/
    https://www.globalresearch.ca/top-pfizer-whistleblower-trashes-company-vaccine-breakthrough-spin/5729650
    jane in toronto

  • Jane Wilson says:

    When an antigen only affects a subset of the population, the elderly and the obese and those with underlying conditions or on certain Rx medications, a vaccine is inappropriate. The problem lies with the host, not the virus. But the medical establishment does not want to talk about that, because there is no profit in improving someone’s health. For polio and ebola, a vaccine might be a good idea. For Covid-19 it is absolutely unnecessary and, just like the swine flu vaccine, it is likely to cause more harm than good.
    I recommend the following sites:
    https://2020news.de/en/dr-wodarg-and-dr-yeadon-request-a-stop-of-all-corona-vaccination-studies-and-call-for-co-signing-the-petition/
    https://www.globalresearch.ca/top-pfizer-whistleblower-trashes-company-vaccine-breakthrough-spin/5729650
    jane in toronto

    • Kirsten says:

      I am a little offended that you’re calling me (the host) the problem when I am immunocompromised and I could not have prevented my condition. You are also saying those lives don’t matter. You are also suggesting front line workers efforts to contain the spread don’t matter. Finally you are not respecting those who have died or their families and loved ones. People are dying, not just from COVID, but from not being able to get necessary treatment and seek early prevention because of COVID restrictions. We can help contain this with very simple and easy to tasks but people cannot follow these. So yes a vaccine is necessary. https://healthydebate.ca/2021/02/topic/pandemic-fears-primary-care/

  • Ron says:

    Do we know yet if the vaccine works only to reduce the symptoms ? or does the vaccine give us immunity? Seems like an important question

  • Ron says:

    Do we know yet if the vaccine works only to reduce the symptoms ? or does the vaccine give us immunity? Seems like an important question

  • Bour says:

    Et pendant ce temps là les labos gagnent des milliards en bourse

  • Bour says:

    Et pendant ce temps là les labos gagnent des milliards en bourse

  • Peter says:

    I kindly ask to the author of this article to please spread out this paper done by researchers a couple of months ago about the dangers of the vaccine possibly developing errant antibodies and make things worst when the wild virus infects a vaccinated person:
    https://www.nature.com/articles/d41587-020-00016-w

    If you are a researcher get access to the article and spread it.

  • Peter says:

    I kindly ask to the author of this article to please spread out this paper done by researchers a couple of months ago about the dangers of the vaccine possibly developing errant antibodies and make things worst when the wild virus infects a vaccinated person:
    https://www.nature.com/articles/d41587-020-00016-w

    If you are a researcher get access to the article and spread it.

  • Ingrid Wilkinson says:

    Hello! Thank you for publishing this educational & Interesting Article! I personally do not approve of a Vaccine that carries unknown Risks; Especially RNA Type vaccines, NEVER before used on Humans! It is extremely irresponsible I find; We have the Nürnberg Code, to protect us from this type of Risk; A Mortality Rate of 0.0003% DOES NOT warrant this type of risk; Please rethink and do the responsible! Serve Humanity not Profits! Thank you!☀️

  • Ingrid Wilkinson says:

    Hello! Thank you for publishing this educational & Interesting Article! I personally do not approve of a Vaccine that carries unknown Risks; Especially RNA Type vaccines, NEVER before used on Humans! It is extremely irresponsible I find; We have the Nürnberg Code, to protect us from this type of Risk; A Mortality Rate of 0.0003% DOES NOT warrant this type of risk; Please rethink and do the responsible! Serve Humanity not Profits! Thank you!☀️

  • Y. Cunnington says:

    Some European experts have concerns about the rushing of the vaccines toward human use without adequate testing. On December 1, 2020, the ex-Pfizer head of respiratory research Dr. Michael Yeadon and the lung specialist and former head of the public health department Dr. Wolfgang Wodarg filed an application with the EMA, the European Medicine Agency responsible for EU-wide drug approval, for the immediate suspension of all SARS CoV 2 vaccine studies, in particular the BioNtech/Pfizer study on BNT162b (EudraCT number 2020-002641-42).

    Dr. Wodarg and Dr. Yeadon demand that the studies – for the protection of the life and health of the volunteers – should not be continued until a study design is available that is suitable to address the significant safety concerns expressed by an increasing number of renowned scientists against the vaccine and the study design.

    On the one hand, the petitioners demand that, due to the known lack of accuracy of the PCR test in a serious study, a so-called Sanger sequencing must be used. This is the only way to make reliable statements on the effectiveness of a vaccine against Covid-19. On the basis of the many different PCR tests of highly varying quality, neither the risk of disease nor a possible vaccine benefit can be determined with the necessary certainty, which is why testing the vaccine on humans is unethical per se.

    Furthermore, they demand that it must be excluded, e.g. by means of animal experiments, that risks already known from previous studies, which partly originate from the nature of the corona viruses, can be realized. The concerns are directed in particular to the following points:

    -The formation of so-called “non-neutralizing antibodies” can lead to an exaggerated immune reaction, especially when the test person is confronted with the real, “wild” virus after vaccination. This so-called antibody-dependent amplification, ADE, has long been known from experiments with corona vaccines in cats, for example. In the course of these studies all cats that initially tolerated the vaccination well died after catching the wild virus.
    -The vaccinations are expected to produce antibodies against spike proteins of SARS-CoV-2. However, spike proteins also contain syncytin-homologous proteins, which are essential for the formation of the placenta in mammals such as humans. It must be absolutely ruled out that a vaccine against SARS-CoV-2 could trigger an immune reaction against syncytin-1, as otherwise infertility of indefinite duration could result in vaccinated women.
    -The mRNA vaccines from BioNTech/Pfizer contain polyethylene glycol (PEG). 70% of people develop antibodies against this substance – this means that many people can develop allergic, potentially fatal reactions to the vaccination.
    -The much too short duration of the study does not allow a realistic estimation of the late effects. As in the narcolepsy cases after the swine flu vaccination, millions of healthy people would be exposed to an unacceptable risk if an emergency approval were to be granted and the possibility of observing the late effects of the vaccination were to follow. Nevertheless, BioNTech/Pfizer apparently submitted an application for emergency approval on December 1, 2020.

    • Ingrid Wilkinson says:

      Thanks you soo much for your Comment & hard work! To Date (7 Dec2020) Mortality Rate in All of Canada: 0.00033% “Active” Cases: 0.0024% For this we Were forced to decimate our Global Economy & I ask how many life’s were lost due to interrupted food chains & Medical supplies alone, across the Globe

    • Sharon Pasula says:

      Thank you so muchfor this.

    • Sjoerd says:

      And don’t forget Pfizer didnt test on people under 15 and at first not above 55 they later included up to 85 but didn’t include or publish the results of above 55 in the application for emergency approval.

  • Y. Cunnington says:

    Some European experts have concerns about the rushing of the vaccines toward human use without adequate testing. On December 1, 2020, the ex-Pfizer head of respiratory research Dr. Michael Yeadon and the lung specialist and former head of the public health department Dr. Wolfgang Wodarg filed an application with the EMA, the European Medicine Agency responsible for EU-wide drug approval, for the immediate suspension of all SARS CoV 2 vaccine studies, in particular the BioNtech/Pfizer study on BNT162b (EudraCT number 2020-002641-42).

    Dr. Wodarg and Dr. Yeadon demand that the studies – for the protection of the life and health of the volunteers – should not be continued until a study design is available that is suitable to address the significant safety concerns expressed by an increasing number of renowned scientists against the vaccine and the study design.

    On the one hand, the petitioners demand that, due to the known lack of accuracy of the PCR test in a serious study, a so-called Sanger sequencing must be used. This is the only way to make reliable statements on the effectiveness of a vaccine against Covid-19. On the basis of the many different PCR tests of highly varying quality, neither the risk of disease nor a possible vaccine benefit can be determined with the necessary certainty, which is why testing the vaccine on humans is unethical per se.

    Furthermore, they demand that it must be excluded, e.g. by means of animal experiments, that risks already known from previous studies, which partly originate from the nature of the corona viruses, can be realized. The concerns are directed in particular to the following points:

    -The formation of so-called “non-neutralizing antibodies” can lead to an exaggerated immune reaction, especially when the test person is confronted with the real, “wild” virus after vaccination. This so-called antibody-dependent amplification, ADE, has long been known from experiments with corona vaccines in cats, for example. In the course of these studies all cats that initially tolerated the vaccination well died after catching the wild virus.
    -The vaccinations are expected to produce antibodies against spike proteins of SARS-CoV-2. However, spike proteins also contain syncytin-homologous proteins, which are essential for the formation of the placenta in mammals such as humans. It must be absolutely ruled out that a vaccine against SARS-CoV-2 could trigger an immune reaction against syncytin-1, as otherwise infertility of indefinite duration could result in vaccinated women.
    -The mRNA vaccines from BioNTech/Pfizer contain polyethylene glycol (PEG). 70% of people develop antibodies against this substance – this means that many people can develop allergic, potentially fatal reactions to the vaccination.
    -The much too short duration of the study does not allow a realistic estimation of the late effects. As in the narcolepsy cases after the swine flu vaccination, millions of healthy people would be exposed to an unacceptable risk if an emergency approval were to be granted and the possibility of observing the late effects of the vaccination were to follow. Nevertheless, BioNTech/Pfizer apparently submitted an application for emergency approval on December 1, 2020.

    • Ingrid Wilkinson says:

      Thanks you soo much for your Comment & hard work! To Date (7 Dec2020) Mortality Rate in All of Canada: 0.00033% “Active” Cases: 0.0024% For this we Were forced to decimate our Global Economy & I ask how many life’s were lost due to interrupted food chains & Medical supplies alone, across the Globe

    • Sharon Pasula says:

      Thank you so muchfor this.

    • Sjoerd says:

      And don’t forget Pfizer didnt test on people under 15 and at first not above 55 they later included up to 85 but didn’t include or publish the results of above 55 in the application for emergency approval.

Author

Catharine Chambers

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Catharine Chambers is a PhD candidate in epidemiology and Vanier Scholar at the Dalla Lana School of Public Health at the University of Toronto.

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