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  • March 2015

    • All About Bleeding: Transfusion targets after cardiac surgery and intracranial bleeding on warfarin

      This week: The TITRE2 trial about hemoglobin transfusion strategies after cardiac surgery and the RETRACE study about intracranial bleeding in patients on warfarin. Nathan and Amol want you to understand the following: 1. In cardiac surgery patients, a restrictive transfusion strategy was no different than liberal transfusion in […]

    • Peanut Placebo, Nocebo, PCSK9: Lipid lowering and peanut allergy

      This week: New studies of PCSK9 inhibitors for lipid lowering and a randomized controlled trial of early peanut exposure to prevent allergy Fahad and Amol want you to understand the following: 1. PCSK9 inhibitors are new cholesterol-lowering monoclonal antibodies that have been shown to reduce LDL beyond […]

    • We turned one! "Too rich for my blood: Obesity, palliative care, hepatitis c"

      Originally aired March 11, 2014: obesity, palliative care, hepatitis c Amol, Fahad, and Travis want you to: 1. Understand trends in obesity prevalence in adults and children. 2. Appreciate the effect of early palliative care on quality of life in patients with advanced cancer. 3. Recognize new therapeutic […]

    • SARAH's VOICE: Pre-exposure prophylaxis in HIV and exercise for the rheumatoid hand

      VOICE: Tenofovir and Emtricitabine for HIV pre-exposure prophylaxis in African women and SARAH: Hand exercises in Rheumatoid Arthritis Fahad and Amol want you to understand the following: 1. Pre-exposure prophylaxis was not effective in a population of African women. Medication adherence was apparently excellent based on self-report […]

  • February 2015

    • Obstetrical Medicine Special: Hypertension and Thrombophilia in Pregnancy

      The CHIPS trial of Hypertension in Pregnancy and TIPPS trial of Thrombophilia in Pregnancy Janice and Amol want you to understand the following: 1. Tight blood pressure control in pregnancy does not affect fetal outcomes in pregnancy compared with loose blood pressure control. The only difference […]

    • The Royal We: Effects of Participation in NSQIP, Steroids for Pneumonia

      Effects of participation in the National Surgical Quality Improvement Program and Prednisone in Community Acquired Pneumonia Nathan and Amol want you to understand the following: 1. Participation in the National Surgical Quality Improvement Program has not appeared to improve overall patient outcomes or cost. 2. Adjunct […]

    • Getting "Travis-y": Stroke and AFib, Naloxegol for Opioid Constipation

      Originally aired July 2, 2014: Cryptogenic Stroke and Atrial Fibrillation, Naloxegol for Opioid-Induced Constipation Fahad and Amol want you to: 1. Appreciate the importance of subclinical atrial fibrillation in cryptogenic stroke and consider longer monitoring to detect it. 2. Recognize Naloxegol as a targeted therapy for opioid-induced constipation that is […]

    • These are not real stock tips: Post-op DVT Prophylaxis and Intra-arterial Treatment of Stroke

      Factor XI Antisense Oligonucleotides for Post-operative VTE and Intra-arterial Treatment for Stroke Nathan and Amol want you to understand the following: 1. Factor XI is a promising treatment target for preventing VTE, with a recent study showing that an antisense oligonucleotide was more effective in reducing […]

  • January 2015

    • Special Gastroenterology Edition with Dr. Samir Grover, Gastro-naut

      Eosinophilic esophagitis Samir and Amol want you to understand the following: 1. Eosinophilic esophagitis is an important and under-recognized clinical condition that causes significant symptoms and is very treatable. 2. Endoscopy, and particularly duodenoscopy, is an important potential source of infection transmission. 3. The rise of […]

    • From SES to Soil: Neighbourhood Disadvantage and A Groundbreaking New Antibiotic

      Neighbourhood Disadvantage and 30-day Rehospitalization; Teixobactin – a Novel Antibiotic Reena and Amol want you to understand the following: 1. Neighbourhood disadvantage was associated with an increased risk of readmission similar to the presence of chronic diseases like COPD. 2. Teixobactin is a new antibiotic […]

    • Best of Hospital Medicine 2013 Part II

      Originally Aired October 1, 2014: Blood Transfusions in Upper GI Bleeding, Aspirin in DVT prophylaxis, Vasopression and Steroids in Cardiac Arrest, MRSA Decolonization, Fluid and Sodium Restriction in Heart Failure Fahad and Amol want you to gain familiarity with a number of major new studies in […]

    • Best of Hospital Medicine 2013 Part I

      Originally Aired September 24, 2014: Fecal Transplantation & Probiotics for C. difficile; Prone Positioning in ARDS; Steroids in COPD; Hospital Management of Diabetes. Fahad and Amol want you to gain familiarity with a number of major studies in hospital medicine published in 2013. 1. Fecal transplantation […]

    • December 2014

    • November 2014

      • Getting Cardiovascular: Baseline Risk and Hypertension Treatment and Dual Antiplatelet Therapy in Coronary Stents

        This Week: Baseline cardiovascular risk calculators and hypertension treatment, and dual antiplatelet treatment after coronary stenting This week, Fahad and Amol want you to understand that: 1. A cardiovascular risk calculator can predict the degree of treatment benefit that patients may derive  from blood pressure treatment. 2. There […]

      • Dubious Acronyms: Handoff Quality and Treating Depression in Cancer Patients

        Implementation of a Handoff Program in Pediatric Hospitals and Treating Depression in Cancer Patients Nathan and Amol want you to: 1.Recognize that a standardized handoff program reduced medical errors in academic pediatric hospitals. 2. Appreciate that a targeted program to treat depression in cancer patients was […]

      • 100% Bullish: Simvastatin in MS, Communicating Risk

        Originally Aired September 10, 2014: Simvastatin in Secondary Progressive Multiple Sclerosis and Communicating With Patients About Risk Rebecca and Amol want you to: 1. Recognize that simvastatin reduces the rate of whole brain atrophy in secondary progressive MS, which may be a promising new use for statins. […]

      • Unintended Puns: Predicting Steroid Response in Asthma and Patient Perceptions of PCI

        This Week: Travis and Amol want you to: 1. Recognize IL-25 levels are good predictors of steroid-responsiveness in asthma. 2. Understand that the majority of patients who undergo elective percutaneous coronary intervention for stable angina are misinformed about its benefits. Continuing Medical Education Internists can receive […]

    • October 2014

      • Health Systems Failures 2: Unplanned Readmissions and Malpractice Reform

        This Week: Reena and Amol want you to: 1. Appreciate the challenges in reducing unplanned readmissions to hospital and concerns about that metric as a quality indicator. 2. Recognize that malpractice reform in three US states did not reduce the intensity of physician practice or resource […]

      • Health System Failures 1: Ebola Basics

        This Week: Reena and Amol want you to: 1. Understand the basics of the Ebola outbreak in West Africa. Continuing Medical Education Internists can receive 0.5 hours of Continuing Medical Education credit for each podcast they listen to through the Canadian Society of Internal Medicine (MOC Category 1) […]

      • Just look at us now: Vagal nerve block for weight loss and stopping inhaled steroids in COPD

        This Week: Vagal nerve blockade for weight loss; stopping inhaled steroids in COPD Nathan and Amol want you to: 1. Learn about vagal nerve blockade as a potential new weight loss intervention 2. Understand that we may be able to safely taper and stop inhaled glucocorticoids in patients with stable […]

      • To a T: Testosterone Supplementation and Reducing Treatment Time in Stroke

        Originally aired April 30, 2014: Cardiovascular risk and testosterone supplementation, reducing time to treatment in acute ischemic stroke. Fahad and Amol want you to: 1. Recognize that observational evidence suggests that testosterone supplementation is significantly associated with cardiovascular events and mortality. 2. Understand that a national quality improvement initiative […]

      • Best of Hospital Medicine 2013 Part II

        This week: Blood Transfusions in Upper GI Bleeding, Aspirin in DVT prophylaxis, Vasopression and Steroids in Cardiac Arrest, MRSA Decolonization, Fluid and Sodium Restriction in Heart Failure Fahad and Amol want you to gain familiarity with a number of major new studies in hospital medicine published […]

    • September 2014

      • Best of Hospital Medicine 2013 Part 1

        This week: Fecal Transplantation & Probiotics for C. difficile; Prone Positioning in ARDS; Steroids in COPD; Hospital Management of Diabetes. Fahad and Amol want you to Gain familiarity with a number of major new studies in hospital medicine published in 2013. 1. Fecal transplantation is effective for […]

      • Heart Success! Bilateral mastectomies in breast cancer, the PARADIGM-HF Heart Failure Trial

        This week: Changes in incidence and mortality associated with bilateral mastectomy for breast cancer and Neprilysin-inhibition for heart failure Nathan and Amol want you to: 1. Recognize that bilateral mastectomies for breast cancer are increasing in incidence, perhaps because of increased use of MRI, and they are […]

      • 100% Bullish: Simvastatin in MS, Communicating Risk

        This week: Simvastatin in Secondary Progressive Multiple Sclerosis and Communicating With Patients About Risk Rebecca and Amol want you to: 1. Recognize that simvastatin reduces the rate of whole brain atrophy in secondary progressive MS, which may be a promising new use for statins. 2. Understand that […]

      • We’re Back (pain)!: Perioperative Atrial Fibrillation, Paracetamol and back pain

        Perioperative AFib and Long-Term Risk of Ischemic Stroke; Paracetamol not more effective than placebo in acute low back pain Nathan and Amol want you to: 1. Understand that perioperative atrial fibrillation is associated with increased long-term risk of ischemic stroke. 2. Recognize that a high quality Randomized Controlled […]

    • August 2014

      • All About Diabetes: Bariatric Surgery and Physical Activity

        Originally aired May 28, 2014: A Randomized Trial of Bariatric Surgery vs. Medical Management; Physical Activity and the Risk of Type II Diabetes in patients with Gestational Diabetes Nathan and Amol want you to: 1. Recognize that bariatric surgery led to superior diabetes control compared to intensive medical management […]

      • Sorry Sports Analogies: Statins in ARDS and COPD, Rotavirus Vaccine

        Originally aired July 9, 2014: Statins for COPD, ARDS and human-bovine Rotavirus vaccine Fahad and Amol want you to: 1. Understand that 2 high quality RCTs demonstrate that statins are not effective in improving clinical outcomes in either COPD or Acute Respiratory Distress Syndrome (ARDS). 2. Recognize that […]

      • Super Cool Stuff: A Bionic Pancreas and Weekly Antibiotics

        Originally aired June 20, 2014: Bionic Pancreas in Type 1 Diabetes and Weekly Dalbavancin for Skin Infections Travis and Amol want you to: 1. Understand the potential role of a novel bionic pancreas in glycemic control in type 1 diabetes. 2. Recognize that dalbavancin is non-inferior to vancomycin/linezolid […]

      • Like A Surgeon: Surgical skill variation, new oral anticoagulants

        Originally aired April 9, 2014: Surgical skill in bariatric surgery and new oral anticoagulants for atrial fibrillation Nathan and Amol want you to: 1. Understand how peer assessed technical skill was found to be associated with complication rates at the individual surgeon level. 2. Recognize […]

    • July 2014

      • They’re coming for Fahad: Air pollution and heart failure, renal denervation

        Originally aired April 25, 2014: Air pollution and heart failure, renal denervation for hypertension. Fahad and Amol want you to: 1. Understand the relationship between air pollution and cardiovascular health, and its broader policy implications. 2. Recognize that renal denervation was not an effective treatment […]

      • A Tale of Two Studies: Medical Male Circumcision, Ischaemic Heart Disease

        This week: Economic Incentives for Voluntary Medical Male Circumcision, and Lifestyle Counselling for Ischaemic Heart Disease Reena and Amol want you to: 1. Understand that medical male circumcision is effective in reducing transmission of HIV and other sexually-transmitted infections. 2. Recognize that an economic incentive designed to […]

      • Physi-Oh My! Physiotherapy for Hip Osteoarthritis and Whiplash

        This week: Physiotherapy in Chronic Hip Osteoarthritis and Whiplash Sara Guilcher and Amol want you to: 1. Recognize that 2 high quality randomized controlled trials showed that a comprehensive physiotherapy intervention did not reduce pain or improve function in chronic hip osteoarthritis or whiplash. 2. […]

      • Sorry Sports Analogies: Statins in ARDS and COPD, Rotavirus Vaccine

        This week: Statins for COPD, ARDS and human-bovine Rotavirus vaccine Fahad and Amol want you to: 1. Understand that 2 high quality RCTs demonstrate that statins are not effective in improving clinical outcomes in either COPD or Acute Respiratory Distress Syndrome (ARDS). 2. Recognize that a novel Rotavirus […]

      • Getting “Travis-y”: Stroke and AFib, Naloxegol for Opioid Constipation

        This week: Cryptogenic Stroke and Atrial Fibrillation, Naloxegol for Opioid-Induced Constipation Fahad and Amol want you to: 1. Appreciate the importance of subclinical atrial fibrillation in cryptogenic stroke and consider longer monitoring to detect it. 2. Recognize Naloxegol as a targeted therapy for opioid-induced constipation that is more effective than placebo […]

    • June 2014

      • Vitamania: Vitamin D and Mortality, Vitamin C and Smoking in Pregnancy

        This week: Vitamin D Levels and All-Cause Mortality, Vitamin C and Infant Lung Outcomes in Pregnant Smokers Reena and Amol want you to: 1. Recognize the potential association between Vitamin D levels and overall mortality. 2. Recognize that Vitamin C supplementation in pregnant women who smoke can improve infant […]

      • Super Cool Stuff: A Bionic Pancreas and Weekly Antibiotics

        This week: Bionic Pancreas in Type 1 Diabetes and Weekly Dalbavancin for Skin Infections Travis and Amol want you to: 1. Understand the potential role of a novel bionic pancreas in glycemic control in type 1 diabetes. 2. Recognize that dalbavancin is non-inferior to vancomycin/linezolid in treating skin […]

      • Yin and Yang 2.0: Revisiting Aspirin and Blood Transfusions

        This week: Perioperative Aspirin and Blood Transfusions and Hospital-acquired Infections Nathan and Amol want you to: 1. Understand that the use of perioperative ASA did not reduce the rate of postoperative MI or death, but was found to increase the rate of major bleeding. 2. Recognize that it […]

      • Filling Buckets: Septic Shock and Asthma

        This week: Protocol-based care for septic shock and a new treatment for allergen-induced asthma Janice and Amol want you to: 1. Recognize the role of protocol-based care in the early recognition and management of septic shock. 2. Recognize that TSLP is a promising new treatment target in allergy-induced asthma. […]

    • May 2014

      • All About Diabetes: Bariatric Surgery and Physical Activity

        This week: A Randomized Trial of Bariatric Surgery vs. Medical Management; Physical Activity and the Risk of Type II Diabetes in patients with Gestational Diabetes Nathan and Amol want you to: 1. Recognize that bariatric surgery led to superior diabetes control compared to intensive medical management in a single […]

      • Great Minds Think Alike: Nurse Staffing and Appropriateness of Coronary Angiography

        This week: Nurse Staffing and Education and Hospital Mortality; Appropriate Use of Coronary Angiography   Nathan and Amol want you to: 1. Understand that this study demonstrated relationships between nurse to patient ratio and average nurse education level to post-operative mortality among a large cohort of European patients. 2. […]

      • Yin and Yang: Aspirin and Surgical Risk and Blood Transfusions and Risk of Infection

        This week: Perioperative Aspirin and Blood Transfusions and Hospital-acquired Infections Nathan and Amol want you to: 1. Understand that the use of perioperative ASA did not reduce the rate of postoperative MI or death, but was found to increase the rate of major bleeding. 2. Recognize that it […]

      • Dropping Names and Dropping Weight: The obesity paradox and new cholesterol guidelines

        This week: Cardiovascular Disease and Population Health Fahad and Amol want you to: 1. Understand that high quality evidence now demonstrates that obesity does not confer a survival benefit in Type 2 Diabetes, and patients should aim to achieve a normal body weight. 2. Recognize that the new cholesterol guidelines […]

    • April 2014

      • To a T: Testosterone Supplementation and Reducing Treatment Time in Stroke

        This week: Cardiovascular risk and testosterone supplementation, reducing time to treatment in acute ischemic stroke. Fahad and Amol want you to: 1. Recognize that observational evidence suggests that testosterone supplementation is significantly associated with cardiovascular events and mortality. 2. Understand that a national quality improvement initiative was associated with […]

      • They’re coming for Fahad: Air pollution and heart failure, renal denervation

        This week: Air pollution and heart failure, renal denervation for hypertension. Fahad and Amol want you to: 1. Understand the relationship between air pollution and cardiovascular health, and its broader policy implications. 2. Recognize that renal denervation was not an effective treatment for hypertension when […]

      • Too Much Tamiflu! Medicaid Expansion and Anti-influenza Medications

        This week: Oregon Medicaid Expansion and a systematic review of anti-influenza medications. Janice and Amol want you to: 1. Understand the effect of health care coverage expansion on health care utilization. 2. Understand the utility of randomized control trials in the formulation of causal inferences. […]

      • Like A Surgeon: Surgical skill variation, new oral anticoagulants

          This week: Surgical skill in bariatric surgery and new oral anticoagulants for atrial fibrillation Nathan and Amol want you to: 1. Understand how peer assessed technical skill was found to be associated with complication rates at the individual surgeon level. 2. Recognize that peer […]

      • How I Met Your D-dimer: Weight loss, pulmonary embolism, and HIV

          This week: Weight loss in colorectal cancer screening, D-dimers in Pulmonary Embolism, and Gene Editing in HIV Nathan, Amol and Travis want you to: 1. Recognize that modifiable lifestyle factors such as inactivity, weight, diet, and alcohol consumption are under-appreciated risk factors for colorectal […]

    • March 2014

      • Fathers and grandfathers of science: checklists, statin myalgia and breast cancer

        This week: surgical checklists, statin myalgia and breast cancer radiotherapy Janice, Nathan, and Amol want you to: 1. Understand the effect of surgical safety checklist implementation on surgical complication rates. 2. Understand the use of n-of-1 trials in evaluating the association between statin use and myalgia. […]

      • Prostatectomy, pharmacare, and protein mutations

        This week: prostatectomy, prescription drug costs, exome sequencing for rare mutations Learning objectives – Amol, Nathan, and Travis discuss: 1. Understand that radical prostatectomy improved overall and disease free survival and decreased metastasis compared with watchful waiting in men with localized prostate cancer of intermediate grade. […]



       Winter2014