This week: Empiric antibiotic choices for community acquired pnuemonia and clindamycin versus trimethoprim-sulfamethoxazole for skin and soft tissue infections.
Fahad and Amol want you to understand the following:
1. A large, high quality RCT showed that there was no significant difference between an empiric treatment strategy of beta-lactam vs beta-lactam plus macrolide vs respiratory fluoroquinolone for the treatment of community-acquired pneumonia requiring hospitalization in a non-ICU setting.
2. A high quality RCT showed that there was no significant difference between clindamycin and TMP-SMX, with respect to either efficacy or side-effect profile, for the treatment of uncomplicated skin infections in regions with endemic Methicillin-Resistant Staphylococcus Aureus.
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