Depression Session: Cardiovascular Outcomes with Antidepressants and Preventing Depression in Primary Care

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This week, Amol and his co-host Reena, general internist at St. Michael’s Hospital in Toronto, discuss two recent papers on depression:

What is the risk of cardiovascular outcomes in patients using antidepressants? A cohort study of patients age 20 to 64 found no evidence that selective serotonin reuptake inhibitors (SSRIs) are associated with increased cardiovascular risk. While the study attempted to avoid indication bias, Reena and Amol wonder whether this was indeed accomplished.

Can depression be prevented in primary care practices? A cluster randomized control trial in Spain found that when primary care providers try to prevent depression based on each patient’s personal risk, the incidence of major depression decreased. However, this result of an absolute difference of 2% was not significant. Amol and Reena discuss possible reasons for this and look to the future.

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The Papers

1. Antidepressants and cardiovascular risk: http://www.bmj.com/content/352/bmj.i1350

2. Preventing depression in primary care: http://annals.org/article.aspx?articleid=2506845

Good Stuff

1. http://www.theglobeandmail.com/news/toronto/neighbours-at-queen-and-bathurst-ready-to-accept-toronto-injection-sites/article29301750/

2. http://www.newyorker.com/magazine/2016/03/28/the-genetics-of-schizophrenia

Music Credits (Creative Commons)

In your Robotic Heart – Nicolai Heidlas https://soundcloud.com/nicolai-heidlas/in-your-robotic-heart

Drive – Nicolai Heidlas https://soundcloud.com/nicolai-heidlas/drive-fresh-upbeat-pop-background-music

Vintage Dream – Nicolai Heidlas https://soundcloud.com/nicolai-heidlas/vintage-dream-loungejazzy-background-music

All tracks have been modified for the purposes of this podcast.

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Amol Verma


Amol Verma is an internal-medicine physician and assistant professor at the University of Toronto.

Reena Pattani


Reena Pattani is a clinician teacher in general internal medicine at St. Michael’s Hospital and assistant professor in the department of medicine at the University of Toronto.