Value Judgments: Whole exome sequencing and left atrial appendage closure devices

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This week, Travis and Amol want you to recognize that:

1. Recognize whole exome sequencing is an important new method of identifying genetic mutations associated with disease.

2. Understand that the 4-year follow-up of the PROTECT AF study showed that left atrial appendage closure devices may be superior to warfarin in preventing strokes in patients with atrial fibrillation.

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The papers

Y Yang et al. Molecular findings among patients referred for clinical whole-exome sequencing. JAMA 2014 Nov 12;312(18):1870-9. (PubMed).

VY Reddy et al.Percutaneous left atrial appendage closure vs warfarin for atrial fibrillation: A Randomized Clinical Trial. JAMA 2014 Nov 19;312(19):1988-98. (PubMed).

Good stuff

Travis: C Ferguson, A Marcus and I Oransky. Publishing: The Peer-Review Scam. Nature. Nov 26, 2014.

Amol: Editorial: How to be good. Lancet Psychiatry. 2014 Dec 1;1(7):485.


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