Getting “Travis-y”: Stroke and AFib, Naloxegol for Opioid Constipation

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Originally aired July 2, 2014: Cryptogenic Stroke and Atrial Fibrillation, Naloxegol for Opioid-Induced Constipation

Fahad and Amol want you to:

1. Appreciate the importance of subclinical atrial fibrillation in cryptogenic stroke and consider longer monitoring to detect it.

2. Recognize Naloxegol as a targeted therapy for opioid-induced constipation that is more effective than placebo but its effectiveness has not been compared directly with existing laxative therapies.

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The papers

David Gladstone et al. Atrial Fibrillation in Patients with Cryptogenic Stroke. NEJM. 2014; 370:2467-2477.

William Chey et al. Naloxegol for Opioid-Induced Constipation in Patients with Noncancer Pain. NEJM. 2014;370:2387-2396.

Other articles mentioned

Tommaso Sanna et al. Cryptogenic stroke and underlying atrial fibrillation. NEJM. 2014;370(26):2478–2486. doi:10.1056/NEJMoa1313600.

Good stuff


Dr. Arnold Relman, 91, Journal Editor and Health System Critic, Dies. Douglas Martin. New York Times. 21 June, 2014.

A Drumbeat on Profit Takers. Abigail Zuger. New York Times. March 19, 2012.

Relman AS. The new medical-industrial complex. N Engl J Med. 1980;303(17):963–970. doi:10.1056/NEJM198010233031703.


The Longitude Prize 2014


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