What is the risk of adverse events after a transient ischemic attack (TIA)? While older studies tell us that the risk of stroke or acute coronary syndrome after a TIA is high in the first 3 months, does this hold true today? An international TIA Registry tried to answer this question by characterizing TIA and …
This week, Amol and Nathan discuss two high profile papers: Authors from the Centres for Disease Control and Prevention (CDC) recently published a report concluding that there is a causal relationship between Zika virus infection and a syndrome of birth defects, notably microcephaly. Nathan and Amol review the evidence the authors presented for this causality, …
This week, Amol and Reena, internist at St. Michael’s hospital in Toronto, discuss the HOPE-3 trial. HOPE-3 is a 2-by-2 double blind randomized placebo controlled trial, which found that statins were effective in preventing cardiovascular events in intermediate risk patients but anti-hypertensives were not. While candesartan and hydrochlorothiazide were not superior to placebo, rosuvastatin resulted …
This week, Amol and his co-host Reena, general internist at St. Michael’s Hospital in Toronto, discuss two recent papers on depression: What is the risk of cardiovascular outcomes in patients using antidepressants? A cohort study of patients age 20 to 64 found no evidence that selective serotonin reuptake inhibitors (SSRIs) are associated with increased cardiovascular …
This week, Amol and Nathan discuss breast cancer and colorectal cancer: Two randomized control trials compared the aromatase inhibitor anastrozole to tamoxifen as adjuvant hormone therapy for postmenopausal women with ductal carcinoma in situ. Both trials were double blind and multi-centred, with one trial (NSABP B-35) enrolling North American patients and the other (IBIS-II DCIS) …
This week, we debut a new format at the Rounds Table. Amol reviews articles published from the latest edition of four journals: Journal of the American Medical Association (JAMA), the Lancet, Annals of Internal Medicine and the New England Journal of Medicine (NEJM). Tune in to hear the latest medical findings, including mindfulness for back …
This week, Amol discusses contrast induced nephropathy. At an overall reported incidence of 10%, contrast induced nephropathy leads to worse clinical outcomes and double the rate of mortality. A systematic review and meta-analysis on the effectiveness of prevention strategies found that there is no strong evidence for any intervention beyond volume expansion with saline. N-acetyl …
This week we are replaying our first episode of the season. Originally aired on January 11, 2016, Amol, general internal medicine resident at the University of Toronto, talk about his 10 favourite papers of 2015. Rate us on iTunes! Follow us on Twitter @roundstable. The Papers 1. Teixobactin, a new antibiotic: http://www.nature.com/nature/journal/v517/n7535/full/nature14098.html 2. Modified Valsalva …
This week, Amol, general internal medicine resident at University of Toronto, and Reena, general internist at St. Michael’s hospital in Toronto, discuss two recent papers: What exactly defines sepsis and how should sepsis be assessed? The Third International Consensus Definitions Task Force worked to define sepsis as “life-threatening organ dysfunction due to a dysregulated host …
This week, Amol, general internal medicine resident at the University of Toronto, and Fahad, staff internist at St. Michael’s Hospital in Toronto, discuss 2 recent papers: Is dementia in decline? A study using the well-characterized Framingham cohort found that dementia rates in the last four decades have declined by 20%. Fahad evaluate the quality of …
This week, Amol, general internal medicine resident at the University of Toronto, and Nathan, general surgery resident also at the University of Toronto, discuss two recent papers: Resident duty hours have been a hotly debated topic for some time. A randomized control trial of United States residency programs compared conventional American duty hour regulations that …
This week, Amol, general internal medicine resident at the University of Toronto, and Fahad, staff internist at St. Michael’s hospital in Toronto, discuss 3 papers: Where do physicians die? What is the intensity of the care they receive at the end of life? Fahad discusses 2 papers that attempted to answer these questions. The first …
This week, Amol, general internal medicine resident at the University of Toronto, discusses the GOLD 2016 COPD management guidelines, and compares it to the new Star Wars movie! While many clinicians will have a well-practiced approach to managing COPD exacerbations, Amol examines the evidence for why we do what we do. He talks about the …
January is Alzheimer Awareness Month in Canada! To bring this to light, Amol and Nathan discuss three recent papers: The first is a systematic review and meta-analysis of risk factors for post-operative delirium. Among other findings, the study identified two nutritional-related variables, low BMI and low albumin, as delirium risk factors. Nathan relates this study to a …
This week, we debut our new “Two Truths, One Lie” segment! Join us and put your knowledge to the test. As always, Amol, general internal medicine resident at the University of Toronto, and Reena, staff physician at St. Michael’s hospital, discuss 2 recent papers: A multi-centred cross over trial conducted in the UK tried to …
Amol, general internal medicine resident at the University of Toronto, and Reena, staff physician in internal medicine at St. Michael’s hospital, discuss 2 recent papers: Opioid prescription is an increasing public health crisis. A retrospective cohort study found that patients who experience non-fatal opioid overdose almost always get re-prescribed opioids at large doses a month …
Happy new year! In our first episode of 2016, Amol, general internal medicine resident at the University of Toronto, talk about his 10 favourite papers of 2015. Rate us on iTunes! Follow us on Twitter @roundstable. The Papers 1. Teixobactin, a new antibiotic: http://www.nature.com/nature/journal/v517/n7535/full/nature14098.html 2. Modified Valsalva manoeuvre: http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2815%2961485-4/abstract 3. Prednisolone or pentoxifylline for alcoholic …
This week, Amol, general internal medicine resident at the University of Toronto, and Fahad, general internist at St. Michael’s hospital in Toronto, discuss two recent papers: Fahad and colleagues recently published a study in JAMA that looks at severe adult undernutrition in low and middle income countries. Using 20-year health survey data collected by USAID, …
This week we are replaying our first episode of the season. Originally aired on September 18, 2015, Amol and Fahad discuss: 1. A randomized controlled trial shows that a new approach to vagal maneuvers for supraventricular tachyarrhythmia was shown to be significantly more effective than traditional maneuvers. 2. A survey in California adolescents shows that there is …
This week, Amol, resident in General Internal Medicine at University of Toronto, and Mike Fralick, chief medical resident at St. Michael’s Hospital in Toronto, talk about 2 blood pressure studies: A meta-analysis and systematic review found that more intensive blood pressure lowering was associated with improved cardiovascular outcomes and albuminuria. Amol discusses the trade-offs of …